Cortisol Dose-Dependently Impairs Migration and Tube-like Formation in a Trophoblast Cell Line and Modulates Inflammatory and Angiogenic Genes

Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of embryo placental tissue itself. Changes in cortisol are associated with impaired trophoblast implantation function, addition to other pregnancy complications. This study aims analyze effects low high doses on an extravillous cell line, various exposures this hormone. SGHPL-4 were treated at five (0–1000 nM) two (continuous: 24 h/day; intermittent: 2 h/day). In intermittent treatment, acted mainly as anti-inflammatory hormone, repressing gene expression kinin B1 receptors, interleukin-6, interleukin-1β. Continuous treatment modulated inflammatory angiogenic pathways, significantly factors their receptors. Cortisol affected migration tube-like structures formation. conclusion, both continuous exposure repressed genes, while only suggesting that a sustained increase is more harmful than short-term increase. also formation, receptors be involved response.